Injurious falls and syncope in older communitydwelling. Systolic blood pressure intervention trial full text view. Patients with any lvef were included in the trial, but inclusion criteria for patients with hfref required established therapies with acei or arb and bb at optimal or besttolerated doses before randomization unless a contraindication or intolerance was documented. Sprint samantha maples, pharmd pgy1 pharmacy resident. The systolic blood pressure intervention sprint trial. Pulmonary artery pressureguided management of patients. The 2015 systolic blood pressure intervention trial sprint studied 9,361 nondiabetic patients. These results thus provide further validation of the 2015 lipid guidelines approach. The systolic blood pressure sbp intervention trial. Submissions from the sprint data analysis challenge on. Systolic blood pressure intervention trial sprint principal results. The sprint trial, funded by the nhlbi arm of the nih and cosponsored by the niddk, nimds and nia, was based on a working group report pdf link from 2007, which identified the question of targeting low blood pressure i.
Sprint csr the official site for press releases, photos, video, audio, pr contact information, presskits and more. A complete list of the members of the systolic blood pressure intervention trial sprint research group is provided in the supplementary appendix, available at. However, it must be remembered that hypertension canada recommends blood pressure to. With at least one of the following cv risk factors. Bp values and categories in patients with inclusionexclusion criteria of the systolic blood pressure intervention sprint trial from. In a clinical trial, the investigators must specify inclusion and exclusion criteria for participation in the study inclusion criteria are characteristics that the prospective subjects must have if they are to be included in the study, while exclusion criteria are those characteristics that disqualify prospective subjects from inclusion in the study. Out of a total of 143 sprint challenge submissions, 29 submissions met our inclusionexclusion criteria and were included for analysis online supplementary appendix i. Ambulatory blood pressure in hypertensive patients with. One possible extension of the sprint findings might be to individuals who are. The systolic blood pressure intervention trial sprint is a 2arm, multicenter, randomized. Supplementary appendix this appendix has been provided by the authors to give readers additional information about their work. Listing a study does not mean it has been evaluated by the u. Suspected whitecoat hypertension, when all of the following criteria is met.
In a communitybased prospective cohort with contemporaneous followup of comparable duration tilda, participants 75 years of age or older who met inclusion criteria for sprint had rates of injurious falls and syncope approximately 5fold higher than the standard care group in sprint. The systolic blood pressure intervention trial sprint the sprint study research group abstract. Sprint randomized trial of tibial fracture fixation the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Generalizability of the sprint results nejm journal watch. Systolic blood pressure intervention trial sprint is an unmasked openlabel randomized controlled clinical trial examining the effect of a high blood pressure treatment strategy aimed at reducing systolic blood pressure sbp to a lower goal than is currently recommended. Sprint randomized trial of tibial fracture fixation. Management of symptomatic orthostatic hypotension see manual of. The systolic blood pressure intervention trial sprint. Systolic blood pressure intervention trial sprint principal results paul k. Generalizability of results from the systolic blood pressure intervention trial. Systolic blood pressure intervention trial sprint protocol version. Tanner rm, hess r, colantonio ld, shimbo d, muntner p.
Blood pressure variability predicts adverse events and. Cox proportional hazards regression was used to identify independent predictors of the sprint primary outcome and adverse events. The following are criteria for the inclusion and exclusion of patients to the phase i stem cell clinical trial underway at johns hopkins and titled. Cushman, md chief, preventive medicine, memphis va medical center. Systolic blood pressure intervention trial sprint aha journals. Heart outcomes prevention evaluation3 american college. Whelton, mb, md, msc chair, sprint steering committee tulane university school of public health and tropical medicine, and school of medicine for the sprint research group. The systolic blood pressure intervention trial sprint is a 2arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure sbp to a lower goal than currently recommended will reduce cardiovascular disease cvd risk. Jackie bosch at the american college of cardiology. A randomized trial of intensive versus standard blood. A randomized trial of intensive versus standard bloodpressure.
Effect of intensive blood pressure lowering on left ventricular hypertrophy in patients with hypertension. Antihypertensive drug management to achieve systolic blood pressure criteria 12, 17. The most common reason for exclusion was that the submission contained no prediction models. Patients were randomized to intensive bp control targeting sbp sprint methods and results. According to the original paper of sprint,12 a total of 9361 participants from the united states and puerto rico were re. The sprint inclusion criteria are presented in table 1. Apply jnc8 recommendations and the sprint trial results appropriately in clinical practice. Systolic blood pressure intervention trial american.